Description
With this Selpercatinib powder you get Selpercatinib as loose powder. Each batch is tested by LC-MS to 99% purity or higher. It’s $179.99. It’s sold for laboratory research only.
It’s also available as Selpercatinib capsules. See all research chemical powders for more options in this format.
What is Selpercatinib?
Selpercatinib (LOXO-292) is a selective RET kinase inhibitor developed by Loxo Oncology, now part of Eli Lilly.
It’s FDA-approved as Retevmo for RET-altered lung and thyroid cancers.
Selpercatinib powder specifications
- Compound: Selpercatinib (LOXO292, ARRY-191)
- CAS number: 2152628-33-4
- Molecular formula: C29H31N7O3
- Molecular weight: 525.61
- Purity: 99% or higher, tested by LC-MS
- Amount: 1g
- Form: Loose powder
- Storage: Store it frozen, at -10°C or colder
- Use: laboratory research only, not for human or veterinary use
Research on Selpercatinib
Drilon and colleagues published the LIBRETTO-001 lung cancer results in the New England Journal of Medicine in 2020.
It’s a standard tool for studying RET signaling.
The original papers are on PubMed if you’d like to read them in full.
Tips for measuring Selpercatinib powder
Loose powder is the most flexible way to buy Selpercatinib. You can weigh any amount you need, dissolve it in your own solvent, or fill your own capsules. It’s also the cheapest format per milligram.
For small amounts you’ll want a scale that reads to at least 0.01g, and ideally 0.001g. Our digital scale and micro scoops make it easier to get consistent measurements. Weigh onto clean weighing paper, and close the bag or jar straight after so the powder doesn’t pick up moisture.
Making a solution from Selpercatinib powder
To make a stock solution, decide on the final volume and concentration first. For 30mL at 10mg/mL you’d weigh 300mg of Selpercatinib, dissolve it in about 25mL of solvent, then top up to exactly 30mL.
Check the compound’s solubility in your chosen solvent before you start, and try a small test amount first. Store the finished solution in a labelled glass bottle.
Purity testing for Selpercatinib
We test each batch of Selpercatinib by LC-MS, which pairs liquid chromatography with mass spectrometry. The chromatography splits the sample into its components and the mass spectrometer identifies them, which tells you both identity and purity. This batch came in at 99% or higher.
Small differences between batches are normal, so write the batch number from the label into your records. If something looks wrong when your order arrives, like discoloured powder or a cloudy solution, set it aside and don’t use it.
Storage and handling
Store it frozen, at -10°C or colder. Use a clean, dry scoop each time, and reseal the container straight away. Label anything you decant with the compound, amount and date, and keep it out of reach of children and pets.
Common questions about the Selpercatinib powder
What can I dissolve Selpercatinib powder in?
That depends on the compound’s solubility and your protocol. Check the solubility data for your solvent first, and test a small amount before making up a full batch.
What scale do I need?
One that reads to 0.01g at minimum, and 0.001g for very small amounts. Our pocket scale reads to 0.01g.
Is the Selpercatinib powder in stock?
Yes. Every option on this page is in stock and ready to ship.
Other research chemicals you might need
Other products in the same range include SR-17018 powder, SANA powder, Tabernanthalog powder and Pyrilutamide powder. Our main Research Chemicals page lists everything in the category.
Buy Selpercatinib powder from Umbrella Labs
Ordering takes a minute. Add it to your cart and check out. The Selpercatinib powder is in stock and ready to ship. If you’re stocking up, take a look at research chemical powders too.
Sold for laboratory research use only. It isn’t for human or veterinary use, and it isn’t a food, drug or cosmetic.
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