Description
The ISRIB powder and capsules from Umbrella Labs come as loose powder or pre-filled capsules. You can choose 2g powder or 60 capsules, 25mg each. Each batch is tested by LC-MS to 99% purity or higher. Prices start at $45.99. It’s sold for laboratory research only.
Browse the rest of our nootropic powders for related compounds.
What is ISRIB?
ISRIB (integrated stress response inhibitor) is a small molecule found at UCSF in Peter Walter’s lab. It stabilises eIF2B so protein synthesis carries on even when the stress response is switched on.
The trans isomer is the active one.
ISRIB powder and capsules specifications
- Compound: ISRIB (trans-ISRIB, ISRIB (trans-isomer), cis-ISRIB)
- CAS number: 1597403-47-8
- Molecular formula: C22H24Cl2N2O4
- Molecular weight: 451.34
- Purity: 99% or higher, tested by LC-MS
- Size: 2g powder and 60 capsules, 25mg each
- Form: Loose powder or capsules
- Storage: Keep it in a cool, dry place away from direct sunlight
- Use: laboratory research only, not for human or veterinary use
ISRIB in published research
Sidrauski and colleagues reported in eLife (2013) that ISRIB improved memory in mice.
Later studies found it restored memory after brain injury and in aged mice.
You can find the papers on PubMed. We don’t make claims beyond what that literature reports.
Powder or capsules: choosing your ISRIB
This listing covers ISRIB in more than one form. The loose powder is the flexible, lower-cost option if you’re weighing your own amounts. The capsules hold a fixed amount each, which saves time when every sample has to be the same.
If you pick the powder, a scale that reads to 0.01g or better is worth having. Our digital scale and micro scoops are made for this kind of work. Either way, keep the container closed tight so moisture stays out.
Making a solution from ISRIB powder
To make a stock solution, decide on the final volume and concentration first. For 30mL at 10mg/mL you’d weigh 300mg of ISRIB, dissolve it in about 25mL of solvent, then top up to exactly 30mL.
Check the compound’s solubility in your chosen solvent before you start, and try a small test amount first. Store the finished solution in a labelled glass bottle.
ISRIB quality and testing
We test each batch of ISRIB by LC-MS, which pairs liquid chromatography with mass spectrometry. The chromatography splits the sample into its components and the mass spectrometer identifies them, which tells you both identity and purity. This batch came in at 99% or higher.
Small differences between batches are normal, so write the batch number from the label into your records. If something looks wrong when your order arrives, like discoloured powder or a cloudy solution, set it aside and don’t use it.
Storing your ISRIB
Keep it in a cool, dry place away from direct sunlight. Use a clean, dry scoop for the powder, and keep both forms sealed between uses. Label anything you decant with the compound, amount and date, and keep it out of reach of children and pets.
Common questions about the ISRIB powder and capsules
What can I dissolve ISRIB powder in?
That depends on the compound’s solubility and your protocol. Check the solubility data for your solvent first, and test a small amount before making up a full batch.
What scale do I need?
One that reads to 0.01g at minimum, and 0.001g for very small amounts. Our pocket scale reads to 0.01g.
Is the ISRIB powder and capsules in stock?
Yes. Every option on this page is in stock and ready to ship.
Related nootropics
Similar products in this format include ITPP powder, Indolepropionamide powder, J147 powder and IDRA-21 powder. Our main Nootropics page lists everything in the category.
Buy ISRIB powder and capsules online
Ordering takes a minute. Pick your option above, add it to your cart and check out. The ISRIB powder and capsules is in stock and ready to ship. Need other compounds for the same study? Browse nootropic powders or our lab supplies.
Sold for laboratory research use only. It isn’t for human or veterinary use, and it isn’t a food, drug or cosmetic.
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