Description
Our Zatolmilast powder comes as loose powder, sold by weight. Each batch is tested by LC-MS to 99% purity or higher. It’s $99.99. It’s sold for laboratory research only.
Prefer a different format? We also stock Zatolmilast capsules and Zatolmilast liquid. Browse the rest of our research chemical powders for related compounds.
What is Zatolmilast?
Zatolmilast (BPN14770) is a PDE4D inhibitor from Tetra Therapeutics. It binds a site found only on the D form of PDE4, which avoids much of the nausea seen with older PDE4 inhibitors.
Raising cAMP in neurons supports memory formation.
Zatolmilast powder specifications
- Compound: Zatolmilast (BPN-14770, compound 28, D159797)
- CAS number: 1606974-33-7
- Molecular formula: C21H15ClF3NO2
- Molecular weight: 405.8
- Purity: 99% or higher, tested by LC-MS
- Amount: 1g
- Form: Loose powder
- Storage: Keep it in a cool, dry place away from direct sunlight
- Use: laboratory research only, not for human or veterinary use
Research on Zatolmilast
Berry-Kravis and colleagues reported in Nature Medicine (2021) improved cognition in adult males with fragile X syndrome.
Phase 3 trials followed.
The original papers are on PubMed if you’d like to read them in full.
Tips for measuring Zatolmilast powder
Buying Zatolmilast as a powder gives you full control. Weigh out exactly what your protocol calls for, make up your own solutions, or encapsulate it yourself.
For small amounts you’ll want a scale that reads to at least 0.01g, and ideally 0.001g. Our digital scale and micro scoops make it easier to get consistent measurements. Weigh onto clean weighing paper, and close the bag or jar straight after so the powder doesn’t pick up moisture.
Making a solution from Zatolmilast powder
To make a stock solution, decide on the final volume and concentration first. For 30mL at 10mg/mL you’d weigh 300mg of Zatolmilast, dissolve it in about 25mL of solvent, then top up to exactly 30mL.
Check the compound’s solubility in your chosen solvent before you start, and try a small test amount first. Store the finished solution in a labelled glass bottle.
Purity testing for Zatolmilast
Every batch of Zatolmilast is checked with liquid chromatography-mass spectrometry (LC-MS) before it goes on sale. LC-MS separates a sample into its parts and identifies each one by mass, so it confirms what the compound is and how much of the sample it makes up. The current batch tested at 99% or higher.
Small differences between batches are normal, so write the batch number from the label into your records. If something looks wrong when your order arrives, like discoloured powder or a cloudy solution, set it aside and don’t use it.
How to store Zatolmilast
Keep it in a cool, dry place away from direct sunlight. Use a clean, dry scoop each time, and reseal the container straight away. Label anything you decant with the compound, amount and date, and keep it out of reach of children and pets.
Common questions about the Zatolmilast powder
What can I dissolve Zatolmilast powder in?
That depends on the compound’s solubility and your protocol. Check the solubility data for your solvent first, and test a small amount before making up a full batch.
What scale do I need?
One that reads to 0.01g at minimum, and 0.001g for very small amounts. Our pocket scale reads to 0.01g.
Is the Zatolmilast powder in stock?
Yes. Every option on this page is in stock and ready to ship.
Other research chemicals you might need
If you’re browsing for a study, you might also look at ZZL-7 powder, VQW-765 powder, TM5614 powder and Tabernanthalog powder. Our main Research Chemicals page lists everything in the category.
Buy Zatolmilast powder from Umbrella Labs
Ready when you are. Add it to your cart and check out. The Zatolmilast powder is in stock and ready to ship. Need other compounds for the same study? Browse research chemical powders or our lab supplies.
Sold for laboratory research use only. It isn’t for human or veterinary use, and it isn’t a food, drug or cosmetic.
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